Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer

Hiroshi Inoue, Kenji Shibuta, Ayumi Matsuyama, Keishi Yoshinaga, Noriaki Sadanaga, Hiroaki Ueo, Graham F. Barnard, Masaki Mori

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens. It has been reported that COMT polymorphism is a representative genetic trait related to the susceptibility of an individual to breast cancer. However, there is no consensus concerning the association between breast cancer in Japanese patients and COMT polymorphism. To analyze the polymorphism distribution in Japanese patients with breast cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was used. Based on an analysis of 201 Japanese patients with breast cancer and 352 healthy control subjects, a significant difference was observed in either the distribution of genotypes (p=0.03) or allele frequencies between the two groups (p=0.01). The relative risk of breast cancer for genotypes (COMTMet/Met and COMTVal/Val) including the variant allele (COMTMet) was 1.47 compared to the wild allele (COMTVal) and homozygote (COMTVal/Val). Furthermore, the distribution of genotypes in post-menopausal patients with breast cancer showed a significant difference with that of healthy subjects of the same menopausal status (p=0.01). No significant difference was found between the distribution of genotypes and clinicopathological features of the cancer. These results suggest that COMT polymorphism may thus be implicated as a genetic trait affecting the susceptibility of an individual to breast cancer in a Japanese population and be an important genetic risk factor in the development of breast cancer in post-menopausal women.

本文言語英語
ページ(範囲)707-712
ページ数6
ジャーナルOncology reports
14
3
DOI
出版ステータス出版済み - 9 2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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