Genetic susceptibility to gastrointestinal cancer: Minireview of the genomewide studies

Masayoshi Tokuoka, Hideshi Ishii, Koshi Mimori, Hiroshi Inoue, Yuichiro Doki, Masaki Mori

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

Background. Recently, comprehensive genomewide studies that identified specific genetic variants in large-scale surveys successfully provided information about gastrointestinal (GI) cancer susceptibility. Methods. We reviewed literature from the last 5 years about the usefulness and updated status of genetic variants, and we noted the implications of large-scale genomewide studies for GI cancer. Results. Comprehensive variant study with large samples has provided information about the genetic variation associated with GI cancer from the difference of observed frequency. This finding has proved to be reproducible regardless of the subject's race or the research method used. Analysis of known or unknown genes near variant loci from statistically significant sites of observed frequency difference could produce important insights into cancer biology. Conclusions. Genetic variant study of large samples will provide many instructive insights into the carcinogenesis, tumor progression, and treatment of GI cancer.

本文言語英語
ページ(範囲)1783-1788
ページ数6
ジャーナルAnnals of Surgical Oncology
16
7
DOI
出版ステータス出版済み - 7 2009

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

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