Genetics of Circadian Rhythms

Tomas S Andreani, Taichi Q Itoh, Evrim Yildirim, Dae-Sung Hwangbo, Ravi Allada

研究成果: Contribution to journalReview article

18 被引用数 (Scopus)

抄録

Nearly all organisms exhibit time-dependent behavior and physiology across a 24-hour day known as circadian rhythms. These outputs are manifestations of endogenous cyclic gene expression patterns driven by the activity of a core transcription/translation feedback loop. Cyclic gene expression determines highly tissue-specific functional activity regulating such processes as metabolic state, endocrine activity, and neural excitability. Entrainment of these cellular clocks is achieved through exogenous daily inputs, such as light and food. Dysregulation of the transcription/translation feedback loop has been shown to result in a wide range of disorders and diseases driving increased interest in circadian therapies.

本文言語英語
ページ(範囲)413-21
ページ数9
ジャーナルSleep Medicine Clinics
10
4
DOI
出版ステータス出版済み - 12 2015

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