Genome-wide association study of genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene

Kenji Wakai, Keitaro Matsuo, Fumihiko Matsuda, Ryo Yamada, Meiko Takahashi, Takahisa Kawaguchi, Yasushi Yatabe, Hidemi Ito, Satoyo Hosono, Kazuo Tajima, Mariko Naito, Emi Morita, Guang Yin, Tatsuhiko Sakamoto, Naoyuki Takashima, Sadao Suzuki, Noriko Nakahata, Haruo Mikami, Keizo Ohnaka, Yoshiyuki WatanabeKokichi Arisawa, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10-5 and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10-5 for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.

本文言語英語
ページ(範囲)2413-2419
ページ数7
ジャーナルObesity
21
11
DOI
出版ステータス出版済み - 11 2013

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学
  • 栄養および糖尿病

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