Genomic Imprinting and Physiological Processes in Mammals

the Erice Imprinting Group

研究成果: Contribution to journalReview article査読

102 被引用数 (Scopus)

抄録

Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role. This Review provides a comprehensive overview of the mechanisms that modulate genomic imprinting and the roles this epigenetic process plays across mammalian physiology.

本文言語英語
ページ(範囲)952-965
ページ数14
ジャーナルCell
176
5
DOI
出版ステータス出版済み - 2 21 2019

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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