Genomic imprinting in mammals: Its life cycle, molecular mechanisms and reprogramming

Yufeng Li, Hiroyuki Sasaki

    研究成果: Contribution to journalReview article査読

    82 被引用数 (Scopus)

    抄録

    Genomic imprinting, an epigenetic gene-marking phenomenon that occurs in the germline, leads to parental-origin-specific expression of a small subset of genes in mammals. Imprinting has a great impact on normal mammalian development, fetal growth, metabolism and adult behavior. The epigenetic imprints regarding the parental origin are established during male and female gametogenesis, passed to the zygote through fertilization, maintained throughout development and adult life, and erased in primordial germ cells before the new imprints are set. In this review, we focus on the recent discoveries on the mechanisms involved in the reprogramming and maintenance of the imprints. We also discuss the epigenetic changes that occur at imprinted loci in induced pluripotent stem cells.

    本文言語英語
    ページ(範囲)466-473
    ページ数8
    ジャーナルCell Research
    21
    3
    DOI
    出版ステータス出版済み - 3 2011

    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Cell Biology

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