Germ cell specification in mice

Katsuhiko Hayashi, Susana M.Chuva De Sousa Lopes, M. Azim Surani

研究成果: Contribution to journalReview article査読

232 被引用数 (Scopus)

抄録

Specification of germ cells in mice occurs relatively late in embryonic development. It is initiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epiblast cells of early postimplantation embryos. Blimp1 represses the incipient somatic program in these cells and promotes progression toward the germ cell fate. Blimp1 may also have a role in the maintenance of early germ cell characteristics by ensuring their escape from the somatic fate as well as possible reversion to pluripotent stem cells.

本文言語英語
ページ(範囲)394-396
ページ数3
ジャーナルScience
316
5823
DOI
出版ステータス出版済み - 4 20 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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