Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients

Keisuke Kawai, Megumi Nakashima, Masayasu Kojima, Sakino Yamashita, Shu Takakura, Miki Shimizu, Chiharu Kubo, Nobuyuki Sudo

研究成果: ジャーナルへの寄稿学術誌査読

19 被引用数 (Scopus)

抄録

Background & aims Ghrelin, a peptide found in the stomach, increases appetite and fat-free mass while suppressing energy expenditure. Ghrelin requires modification by medium-chain triglycerides (MCTs) to exert its physiological effects. In this study, we investigated ghrelin activation and the resulting physiological changes following MCT administration. Methods Thirty participants were selected from among inpatients diagnosed with anorexia nervosa (AN). The patients were randomly divided into three groups by the MCT content of their nutritional supplement: (1) ‘MCT high’ (>6 g/day), (2) ‘MCT moderate’ (1–6 g/day), and (3) ‘MCT low’ (<1 g/day). Physical factors such as body weight and composition, as well as levels of nutrition-related serum factors such as acylated (active form) and desacyl (inactive form) ghrelin, leptin, growth hormone, insulin-like growth factor, and neuropeptide Y (NPY) were measured at weeks 0, 2, 4, and 6 of the treatment protocol. Results Significantly higher ghrelin activation was found in the ‘MCT high’ than in the ‘MCT low’ group (P < 0.05). The amount of consumed MCT had a curvilinear relationship with the active ghrelin level (P = 0.00). NPY levels in the ‘MCT high’ group were significantly more elevated than in the ‘MCT low’ group (P < 0.05). MCT administration did not significantly affect the remaining factors. Conclusions This study clearly demonstrated that MCT activates ghrelin and increases NPY, suggesting that nutritional supplementation with MCT may be effective for the treatment of AN patients in an emaciated state.

本文言語英語
ページ(範囲)100-104
ページ数5
ジャーナルClinical Nutrition ESPEN
17
DOI
出版ステータス出版済み - 2月 1 2017

!!!All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 栄養および糖尿病

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