Glasgow prognostic score (GPS) can be a useful indicator to determine prognosis of patients with colorectal carcinoma

Tadahiro Nozoe, Rumi Matono, Hideki Ijichi, Takefumi Ohga, Takahiro Ezaki

研究成果: Contribution to journalArticle査読

30 被引用数 (Scopus)

抄録

The Glasgow Prognostic Score (GPS), an inflammation-based score, has been used to predict the biologic behavior of malignant tumors. The aim of the current study was to elucidate a further significance of GPS in colorectal carcinoma. Correlation of GPS and modified GPS (mGPS), which are composed of combined score provided for serum elevation of C-reactive protein and hypoalbuminemia examined before surgical treatment, with clinicopathologic features was investigated in 272 patients with colorectal carcinoma. Survival of GPS 1 patients was significantly worse than that of GPS 0 patients (P = 0.009), and survival of GPS 2 patients was significantly worse than that of GPS 1 patients (P < 0.0001). Similarly, survival of mGPS 1 patients was significantly worse than that of mGPS 0 patients (P = 0.009), and survival of mGPS 2 patients was significantly worse than that of mGPS 1 patients (P = 0.0006). Multivariate analysis demonstrated that GPS (P < 0.0001) as well as tumor stage (P=0.004) and venous invasion (P = 0.011) were factors independently associated with worse prognosis. Both GPS and mGPS could classify outcome of patients with a clear stratification, and could be applied as prognostic indicators in colorectal carcinoma.

本文言語英語
ページ(範囲)512-517
ページ数6
ジャーナルInternational Surgery
99
4
DOI
出版ステータス出版済み - 2014

All Science Journal Classification (ASJC) codes

  • Surgery

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