GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor

Guangchun Chen, Yutaka Goto, Ryuichi Sakamoto, Kimitaka Tanaka, Eri Matsubara, Masafumi Nakamura, Hong Zheng, Jian Lu, Ryoichi Takayanagi, Masatoshi Nomura

研究成果: Contribution to journalArticle査読

36 被引用数 (Scopus)

抄録

Sonic hedgehog (SHH) signaling, acting in a combinatorial manner with androgen signaling, is essential for prostate patterning and development. Recently, elevated activation of SHH signaling has been shown to play important roles in proliferation, progression and metastasis of prostate cancer. In this report, we demonstrate for the first time, that GLI1, which has been shown to play a central role in SHH signaling in prostate cancer, can act as a co-repressor to substantially block androgen receptor (AR)-mediated transactivation, at least in part, by directly interacting with AR. Our observations suggest that the SHH-GLI pathway might be one of determinants governing the transition of prostate cancer from an. androgen-dependent to an androgen-independent state by compensating, or even superseding androgen signaling.

本文言語英語
ページ(範囲)809-815
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
404
3
DOI
出版ステータス出版済み - 1 21 2011

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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