Glomerural crescent formation in renal amyloidosis: A clinicopathological study and demonstration of upregulated cell-mediated immunity

K. Masutani, M. Nagata, H. Ikeda, K. Takeda, R. Katafuchi, H. Hirakata, K. Tsuruya, M. Iida

研究成果: ジャーナルへの寄稿記事

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Background: Several studies examined glomerular crescents associated with renal amyloidosis. However, the incidence of crescents, the association between the 2 lesions, treatment and outcome are still controversial. Patients and methods: We studied 107 consecutive biopsies of renal amyloidosis, and found cellular or fibrocellular crescents in 13 cases (12.1%). We investigated the clinical characteristics, pathological findings, treatment and outcome. We also performed immunohistochemical staining using T cell, macrophage and osteopontin (OPN) markers. Results: Amyloid was of the AA type in 12 cases, and all patients had rheumatoid arthritis. Six cases with AA amyloidosis had crescentic glomerulonephritis (CrGN), and 5 presented with rapidly progressive glomerulonephritis (RPGN). The percentage of crescents correlated negatively with serum albumin (r = -0.83, p < 0.001), and positively with serum creatinine (r = 0.72, p < 0.01) and urinary protein excretion (r = 0.85, p < 0.001). All RPGN patients developed end-stage renal disease, and 2 patients died shortly after treatment. Microscopic examination showed inflammatory cells within the glomeruli, and immunohistochemical study revealed abundant intrarenal T cells and macrophages in CrGN cases. Strong expression of OPN was observed in tubular epithelial cells and intraglomerular macrophages. Conclusion: Cellular immune responses play a crucial role in glomerular crescents in renal amyloidosis. Immunosuppressive treatment is often ineffective and raises the risk of complications in CrGN with abundant glomerular sclerosis and tubulointerstitial injury.

元の言語英語
ページ(範囲)464-474
ページ数11
ジャーナルClinical nephrology
70
発行部数6
出版物ステータス出版済み - 12 1 2008

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Nephrology

これを引用

Masutani, K., Nagata, M., Ikeda, H., Takeda, K., Katafuchi, R., Hirakata, H., ... Iida, M. (2008). Glomerural crescent formation in renal amyloidosis: A clinicopathological study and demonstration of upregulated cell-mediated immunity. Clinical nephrology, 70(6), 464-474.