Glucose inhibits prostacyclin production by cultured aortic endothelial cells

H. Ono, F. Umeda, T. Inoguchi, H. Ibayashi

    研究成果: ジャーナルへの寄稿記事

    44 引用 (Scopus)

    抄録

    A reduction in production of prostacyclin (PGI2) by the cells in the vascular wall may play a role in the pathogenesis of atherosclerosis in diabetic patients. The present study was undertaken to evaluate the effect of glucose on PGI2 production by endothelial cells in vitro. It was shown that PGI2 production by cultured bovine aortic endothelial cells was significantly reduced in the presence of a high concentration of glucose (300 mg/dl) compared with physiological concentrations of glucose (100 mg/dl). In contrast, no reduction in PGI2 production was observed in cells cultured with equimolar mannitol, suggesting that glucose itself, rather than the effect of osmolality, inhibited PGI2 production by cultured endothelial cells. In addition, a high concentration of glucose also inhibited the proliferation of cultured endothelial cells.

    元の言語英語
    ページ(範囲)174-177
    ページ数4
    ジャーナルThrombosis and Haemostasis
    60
    発行部数2
    出版物ステータス出版済み - 1 1 1988

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    Epoprostenol
    Endothelial Cells
    Glucose
    Cultured Cells
    Mannitol
    Osmolar Concentration
    Blood Vessels
    Atherosclerosis

    All Science Journal Classification (ASJC) codes

    • Hematology

    これを引用

    Ono, H., Umeda, F., Inoguchi, T., & Ibayashi, H. (1988). Glucose inhibits prostacyclin production by cultured aortic endothelial cells. Thrombosis and Haemostasis, 60(2), 174-177.

    Glucose inhibits prostacyclin production by cultured aortic endothelial cells. / Ono, H.; Umeda, F.; Inoguchi, T.; Ibayashi, H.

    :: Thrombosis and Haemostasis, 巻 60, 番号 2, 01.01.1988, p. 174-177.

    研究成果: ジャーナルへの寄稿記事

    Ono, H, Umeda, F, Inoguchi, T & Ibayashi, H 1988, 'Glucose inhibits prostacyclin production by cultured aortic endothelial cells', Thrombosis and Haemostasis, 巻. 60, 番号 2, pp. 174-177.
    Ono, H. ; Umeda, F. ; Inoguchi, T. ; Ibayashi, H. / Glucose inhibits prostacyclin production by cultured aortic endothelial cells. :: Thrombosis and Haemostasis. 1988 ; 巻 60, 番号 2. pp. 174-177.
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