TY - JOUR
T1 - Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG
AU - Kumazoe, Motofumi
AU - Tanaka, Yasutake
AU - Yoshitomi, Ren
AU - Marugame, Yuki
AU - Lee, Kwan Woo
AU - Onda, Hiroaki
AU - Fujimura, Yoshinori
AU - Yonekura, Madoka
AU - Shimamoto, Yasuyo
AU - Tachibana, Hirofumi
N1 - Funding Information:
This is work was supported in part by JSPS KAKENHI Grant, JP15H02448 and JP20H05683 to H. Tachibana, JP20K05960 to M. Kumazoe.
Publisher Copyright:
© 2021, The Japanese Society of Pharmacognosy.
PY - 2021/9
Y1 - 2021/9
N2 - Animal and clinical studies have revealed that (–)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.
AB - Animal and clinical studies have revealed that (–)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.
UR - http://www.scopus.com/inward/record.url?scp=85107777559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107777559&partnerID=8YFLogxK
U2 - 10.1007/s11418-021-01538-6
DO - 10.1007/s11418-021-01538-6
M3 - Comment/debate
AN - SCOPUS:85107777559
VL - 75
SP - 1037
EP - 1042
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1340-3443
IS - 4
ER -
