TY - JOUR
T1 - Glucuronidation and the UDP-glucuronosyltransferases in health and disease
AU - Wells, Peter G.
AU - Mackenzie, Peter I.
AU - Chowdhury, Jayanta Roy
AU - Guillemette, Chantal
AU - Gregory, Philip A.
AU - Ishii, Yuji
AU - Hansen, Antony J.
AU - Kessler, Fay K.
AU - Kim, Perry M.
AU - Chowdhury, Namita Roy
AU - Ritter, Joseph K.
PY - 2004/3
Y1 - 2004/3
N2 - This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.
AB - This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies.
UR - http://www.scopus.com/inward/record.url?scp=10744227696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744227696&partnerID=8YFLogxK
U2 - 10.1124/dmd.32.3.281
DO - 10.1124/dmd.32.3.281
M3 - Article
C2 - 14977861
AN - SCOPUS:10744227696
VL - 32
SP - 281
EP - 290
JO - Drug Metabolism and Disposition
JF - Drug Metabolism and Disposition
SN - 0090-9556
IS - 3
ER -
