Glutamate receptor subtypes may be classified into two major categories: A study on Xenopus oocytes injected with rat brain mRNA

Hiroyuki Sugiyama, Isao Ito, Masakazu Watanabe

研究成果: Contribution to journalArticle査読

124 被引用数 (Scopus)

抄録

Three major subtypes of glutamate receptors that are coupled to cation channels are known. Recently an additional subtype that is coupled to G proteins and stimulates inositol phospholipid metabolism (the metabotropic glutamate receptor) has been proposed. The pharmacological characteristics of this receptor have now been examined. Although it shares some agonists with N-methyl-d-aspartate- and quisqualate-subtype receptors, it shares virtually no antagonists with any of the three cation channel-coupled receptor subtypes. Thus the metabotropic glutamate receptor belongs to a receptor category that is completely different from that of the other three receptor subtypes, not only functionally, but also pharmacologically.

本文言語英語
ページ(範囲)129-132
ページ数4
ジャーナルNeuron
3
1
DOI
出版ステータス出版済み - 7 1989

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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