Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier

Hideki Matsune, Tomoya Ono, Ryoya Yoshida, Tsuyoshi Yamamoto, Masahiro Kishida

研究成果: ジャーナルへの寄稿記事

抄録

A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.

元の言語英語
ページ(範囲)1058-1061
ページ数4
ジャーナルChemistry Letters
48
発行部数9
DOI
出版物ステータス出版済み - 1 1 2019

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Drug Carriers
Drug delivery
Doxorubicin
Glutathione
Zinc
Nanostructures
Ions
Nanoparticles
Decomposition
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier. / Matsune, Hideki; Ono, Tomoya; Yoshida, Ryoya; Yamamoto, Tsuyoshi; Kishida, Masahiro.

:: Chemistry Letters, 巻 48, 番号 9, 01.01.2019, p. 1058-1061.

研究成果: ジャーナルへの寄稿記事

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