Glutathione S-transferase polymorphisms and risk of colorectal adenomas

Hisako Inoue, Chikako Kiyohara, Sachiko Shinomiya, Tomomi Marugame, Emiko Tsuji, Koichi Handa, Hitomi Hayabuchi, Hiroyuki Eguchi, Yoshitaka Fukushima, Suminori Kono

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

Glutathione S-transferases (GSTs) are a superfamily of detoxification enzymes that may play an important role in human carcinogenesis. While the genetic polymorphisms GSTM1 and GSTT1 have drawn particular interest in relation to cancer susceptibility, previous studies of colorectal cancer are inconsistent regarding their role. We examined the relation between GSTM1 and GSTT1 genotypes combined and colorectal adenomas, and the interaction with cigarette smoking among 205 cases of colorectal adenomas and 220 controls with normal total colonoscopy in Japanese men. Neither GSTM1 nor GSTT1 was related to colorectal adenomas, nor were the null genotypes of GSTM1 and GSTT1 combined. The lack of an association with GSTM1 and GSTT1 genotypes combined persisted even when the analysis was done separately for proximal and distal colorectal adenomas. A three- to fivefold significant increase in the odds of colorectal adenomas was observed among men with a high exposure to cigarette smoking across the genotype groups, and a statistically significant increasing trend was noted within each genotype group. The present findings do not support the role for GSTM1 and GSTT1 genotypes in the development of colorectal adenomas.

本文言語英語
ページ(範囲)201-206
ページ数6
ジャーナルCancer Letters
163
2
DOI
出版ステータス出版済み - 2 26 2001

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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