Glycated albumin as a diagnostic tool for diabetes in a general Japanese population

Hiroaki Ikezaki, Norihiro Furusyo, Takeshi Ihara, Takeo Hayashi, Kazuya Ura, Satoshi Hiramine, Fujiko Mitsumoto, Koji Takayama, Murata Masayuki, Takuji Kohzuma, Masumi Ai, Ernst J. Schaefer, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

Objective Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus. Design and methods A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9 mmol/l, and an HbA1c level of < 6.5% received an oral glucose tolerance test (OGTT). Results The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2% for GA and 5.9% for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1% for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9%, while for HbA1c it was higher at 66.7%. Conclusions Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.

元の言語英語
ページ(範囲)698-705
ページ数8
ジャーナルMetabolism: Clinical and Experimental
64
発行部数6
DOI
出版物ステータス出版済み - 6 1 2015

Fingerprint

Diabetes Mellitus
Population
Glucose Tolerance Test
Fasting
Glucose
Eye Diseases
Glycosylated Hemoglobin A
Kidney Diseases
Nervous System Diseases
Serum Albumin
ROC Curve
Life Style
Cardiovascular Diseases
glycosylated serum albumin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Ikezaki, H., Furusyo, N., Ihara, T., Hayashi, T., Ura, K., Hiramine, S., ... Hayashi, J. (2015). Glycated albumin as a diagnostic tool for diabetes in a general Japanese population. Metabolism: Clinical and Experimental, 64(6), 698-705. https://doi.org/10.1016/j.metabol.2015.03.003

Glycated albumin as a diagnostic tool for diabetes in a general Japanese population. / Ikezaki, Hiroaki; Furusyo, Norihiro; Ihara, Takeshi; Hayashi, Takeo; Ura, Kazuya; Hiramine, Satoshi; Mitsumoto, Fujiko; Takayama, Koji; Masayuki, Murata; Kohzuma, Takuji; Ai, Masumi; Schaefer, Ernst J.; Hayashi, Jun.

:: Metabolism: Clinical and Experimental, 巻 64, 番号 6, 01.06.2015, p. 698-705.

研究成果: ジャーナルへの寄稿記事

Ikezaki, H, Furusyo, N, Ihara, T, Hayashi, T, Ura, K, Hiramine, S, Mitsumoto, F, Takayama, K, Masayuki, M, Kohzuma, T, Ai, M, Schaefer, EJ & Hayashi, J 2015, 'Glycated albumin as a diagnostic tool for diabetes in a general Japanese population', Metabolism: Clinical and Experimental, 巻. 64, 番号 6, pp. 698-705. https://doi.org/10.1016/j.metabol.2015.03.003
Ikezaki, Hiroaki ; Furusyo, Norihiro ; Ihara, Takeshi ; Hayashi, Takeo ; Ura, Kazuya ; Hiramine, Satoshi ; Mitsumoto, Fujiko ; Takayama, Koji ; Masayuki, Murata ; Kohzuma, Takuji ; Ai, Masumi ; Schaefer, Ernst J. ; Hayashi, Jun. / Glycated albumin as a diagnostic tool for diabetes in a general Japanese population. :: Metabolism: Clinical and Experimental. 2015 ; 巻 64, 番号 6. pp. 698-705.
@article{a9b45ca774184400ae0244341e085e81,
title = "Glycated albumin as a diagnostic tool for diabetes in a general Japanese population",
abstract = "Objective Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus. Design and methods A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9 mmol/l, and an HbA1c level of < 6.5{\%} received an oral glucose tolerance test (OGTT). Results The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2{\%} for GA and 5.9{\%} for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1{\%} for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9{\%}, while for HbA1c it was higher at 66.7{\%}. Conclusions Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.",
author = "Hiroaki Ikezaki and Norihiro Furusyo and Takeshi Ihara and Takeo Hayashi and Kazuya Ura and Satoshi Hiramine and Fujiko Mitsumoto and Koji Takayama and Murata Masayuki and Takuji Kohzuma and Masumi Ai and Schaefer, {Ernst J.} and Jun Hayashi",
year = "2015",
month = "6",
day = "1",
doi = "10.1016/j.metabol.2015.03.003",
language = "English",
volume = "64",
pages = "698--705",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Glycated albumin as a diagnostic tool for diabetes in a general Japanese population

AU - Ikezaki, Hiroaki

AU - Furusyo, Norihiro

AU - Ihara, Takeshi

AU - Hayashi, Takeo

AU - Ura, Kazuya

AU - Hiramine, Satoshi

AU - Mitsumoto, Fujiko

AU - Takayama, Koji

AU - Masayuki, Murata

AU - Kohzuma, Takuji

AU - Ai, Masumi

AU - Schaefer, Ernst J.

AU - Hayashi, Jun

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus. Design and methods A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9 mmol/l, and an HbA1c level of < 6.5% received an oral glucose tolerance test (OGTT). Results The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2% for GA and 5.9% for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1% for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9%, while for HbA1c it was higher at 66.7%. Conclusions Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.

AB - Objective Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus. Design and methods A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9 mmol/l, and an HbA1c level of < 6.5% received an oral glucose tolerance test (OGTT). Results The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2% for GA and 5.9% for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1% for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9%, while for HbA1c it was higher at 66.7%. Conclusions Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=84927970888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927970888&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2015.03.003

DO - 10.1016/j.metabol.2015.03.003

M3 - Article

VL - 64

SP - 698

EP - 705

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 6

ER -