Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle

Yuki Hattori, Daisuke Morita, Nagatoshi Fujiwara, Daiki Mori, Takashi Nakamura, Hideyoshi Harashima, Sho Yamasaki, Masahiko Sugita

    研究成果: Contribution to journalArticle査読

    52 被引用数 (Scopus)

    抄録

    Background:Ahost receptor has not yet been identified for glycerol monomycolate (GroMM), an immunostimulatory lipid of mycobacteria. Results: GroMM recognition occurred in cell transfectants expressing human, but not mouse Mincle. Human Mincle transgenic mice acquired the ability to respond to GroMM. Conclusion: GroMM is a ligand for human Mincle. Significance: The molecular basis underlying the innate immune recognition of GroMM has been elucidated.

    本文言語英語
    ページ(範囲)15405-15412
    ページ数8
    ジャーナルJournal of Biological Chemistry
    289
    22
    DOI
    出版ステータス出版済み - 5 30 2014

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 分子生物学
    • 細胞生物学

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