Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug

masaki arioka, Fumi Takahashi-Yanaga

研究成果: ジャーナルへの寄稿評論記事

抄録

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes swelling, bone erosion, and joint disorder. Patients with RA therefore suffer from pain and physiological disability, and have a decreased quality of life. During the progression of RA, many different types of cells and inflammatory factors influence each other with an important role. A better understanding of the pathology of RA should therefore lead to the development of effective anti-rheumatoid drugs, such as the anti-TNFα antibody. Glycogen synthase kinase-3 (GSK-3) is a cytoplasmic serine/threonine protein kinase that is involved in a large number of key cellular processes and is dysregulated in a wide variety of diseases, including inflammation and osteoporosis. The accumulated evidence has suggested that GSK-3 could be involved in multiple steps in the progression of RA. In the present review, the mechanisms of the pathogenesis of RA are summarized, and recent developments and potential new drugs targeting GSK-3 are discussed.

元の言語英語
ページ(範囲)207-213
ページ数7
ジャーナルBiochemical Pharmacology
165
DOI
出版物ステータス出版済み - 7 1 2019

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Glycogen Synthase Kinase 3
Rheumatoid Arthritis
Pharmaceutical Preparations
Protein-Serine-Threonine Kinases
Pathology
Swelling
Erosion
Bone
Antibodies
Joint Diseases
Drug Delivery Systems
Osteoporosis
Anti-Idiotypic Antibodies
Joints
Quality of Life
Inflammation
Bone and Bones
Pain

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

これを引用

Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug. / arioka, masaki; Takahashi-Yanaga, Fumi.

:: Biochemical Pharmacology, 巻 165, 01.07.2019, p. 207-213.

研究成果: ジャーナルへの寄稿評論記事

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