Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug

Masaki Arioka, Fumi Takahashi

研究成果: ジャーナルへの寄稿総説査読

8 被引用数 (Scopus)


Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes swelling, bone erosion, and joint disorder. Patients with RA therefore suffer from pain and physiological disability, and have a decreased quality of life. During the progression of RA, many different types of cells and inflammatory factors influence each other with an important role. A better understanding of the pathology of RA should therefore lead to the development of effective anti-rheumatoid drugs, such as the anti-TNFα antibody. Glycogen synthase kinase-3 (GSK-3) is a cytoplasmic serine/threonine protein kinase that is involved in a large number of key cellular processes and is dysregulated in a wide variety of diseases, including inflammation and osteoporosis. The accumulated evidence has suggested that GSK-3 could be involved in multiple steps in the progression of RA. In the present review, the mechanisms of the pathogenesis of RA are summarized, and recent developments and potential new drugs targeting GSK-3 are discussed.

ジャーナルBiochemical Pharmacology
出版ステータス出版済み - 7月 2019

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 薬理学


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