Glycoglycan Mimic by Synthetic Polymers

Yoshiko Miura, Tomohiro Fukuda, Yu Hoshino

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

Glycosaminoglycans (GAGs) are important polysaccharides in the living system, but the availability of GAGs is limited due to the complicated structures. In this investigation, GAGs were re-organized by synthetic glycopolymers. GAGs mimic glycopolymers were synthesized by polymerization of acrylamide sugar derivatives carrying sulfated N-acetyl glucosamine (GlcNAc). The interaction with proteins were investigated in view of inhibition of Alzheimer disease. The glycopolymer were prepared as molecular library with changing molecular weight, sugar structure and sugar ratios. The inhibitory activity of Alzheimer disease was studied by inhibitions of protein amyloidosis of amyloid beta (Aβ) peptides. The biological activities depended on the chemical structure of glycopolymers. We found the correlation of glycopolymer activities to the native GAGs.

本文言語英語
ホスト出版物のタイトルACS Symposium Series
編集者Yoshihiro Ito, Xuesi Chen, Inn-Kyu Kang
出版社American Chemical Society
ページ69-77
ページ数9
DOI
出版ステータス出版済み - 2017

出版物シリーズ

名前ACS Symposium Series
1253
ISSN(印刷版)0097-6156
ISSN(電子版)1947-5918

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)

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