Glycopolymers Mimicking GM1 Gangliosides: Cooperativity of Galactose and Neuraminic Acid for Cholera Toxin Recognition

Yuhei Terada, Yu Hoshino, Yoshiko Miura

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Glycopolymers mimicking GM1 gangliosides were synthesized by incorporating multiple types of carbohydrates into the polymer backbone. The glycopolymers were immobilized onto gold surfaces, and the interactions with the cholera toxin B subunit (CTB) were analyzed using surface plasmon resonance imaging. The glycopolymer containing both galactose and neuraminic acid showed enhanced recognition of CTB. The interaction was enhanced mainly because of an improvement in the dissociation process by the binding of the neuraminic acid group in the GM1 binding pocket. This cooperativity of galactose and neuraminic acid was achieved by incorporation into the same flexible polymer backbone, and the importance of the close placement of galactose and neuraminic acid groups was revealed. These results will be valuable in medical fields and also for the development of biofunctional materials.

本文言語英語
ページ(範囲)1021-1027
ページ数7
ジャーナルChemistry - An Asian Journal
14
7
DOI
出版ステータス出版済み - 4 1 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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