Glycosaminoglycans and glycosylphosphatidylinositol-anchor proteins in development of caenorhabditis elegans

Kazuya Nomura, Sayaka Akiyoshi, Ayako Matsuda, Kazuko H. Nomura

研究成果: Chapter in Book/Report/Conference proceedingChapter

抄録

Glycosaminoglycans (GAGs) and glycosylphosphatidylinositol (GPI)-anchored proteins play various roles in the development of multicellular organisms. Caenorhabditis elegans is an excellent model organism to study the role of glycoconjugates in development and morphogenesis because genetically identical organisms are easy to collect in large numbers, and the knowledge of its genomic sequence enables quick and effective gene knockout or knockdown analysis. RNA interference (RNAi), deletion mutagenesis, and the recently developed genome-editing techniques can be easily applied to this model organism. Genetic and biochemical analysis are relatively simple, and owing to C. elegans’ transparent body, cell lineage analysis can be carried out easily. The presence of GPI-anchored proteins (GPI-APs) and GAGs has previously been established in this model organism, and the major genes responsible for their synthesis have been identified. Functional inhibition of these genes revealed that GPI-APs and GAGs play essential roles in germline formation, early embryonic cell division, early morphogenesis, and in the development of the nervous system.

本文言語英語
ホスト出版物のタイトルGlycoscience
ホスト出版物のサブタイトルBiology and Medicine
出版社Springer Japan
ページ817-824
ページ数8
ISBN(電子版)9784431548416
ISBN(印刷版)9784431548409
DOI
出版ステータス出版済み - 1 1 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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