Glycosyl phosphites as glycosylation reagents

Shin Aoki, Hirosato Kondo, Chi Huey Wong

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

This chapter describes the application of glycosyl phosphites to the synthesis of different types of glycosides. The development of new methods for the efficient construction of glycosidic bonds is an objective of current research in carbohydrate synthesis. The practical and stereo controlled synthesis of oligosaccharides containing sialic acid, for example, remains of particular interest because of their important roles in biological recognition and cellular communication. However, the steric hindrance of the anomeric center and the ease of elimination during activation and glycosylation make the sialylation reaction particularly difficult to execute in a high-yield and stereoselective manner. A novel and high-yield sialylation using sialyl phosphite as donor and trimethylsilyltrifluoromethane sulfonate (TMSOTf) as catalyst has been illustrated in the chapter.

本文言語英語
ページ(範囲)193-211
ページ数19
ジャーナルMethods in enzymology
247
C
DOI
出版ステータス出版済み - 1 1 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

フィンガープリント

「Glycosyl phosphites as glycosylation reagents」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル