GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

Kenjiro Date, Takao Ohtsuka, Takaaki Fujimoto, Yoshitaka Gotoh, Yohei Nakashima, Hideyo Kimura, Taketo Matsunaga, Yasuhisa Mori, Naoki Mochidome, Tetsuyuki Miyazaki, Yoshinao Oda, Masao Tanaka, Masafumi Nakamura

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.

本文言語英語
ページ(範囲)713-716
ページ数4
ジャーナルPancreatology
15
6
DOI
出版ステータス出版済み - 2015

!!!All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 肝臓学
  • 消化器病学

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