GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual

A case report

Kenjiro Date, Ohtsuka Takao, Takaaki Fujimoto, Yoshitaka Gotoh, Yohei Nakashima, Hideyo Kimura, Taketo Matsunaga, Yasuhisa Mori, Naoki Mochidome, Tetsuyuki Miyazaki, Yoshinao Oda, Masao Tanaka, Masafumi Nakamura

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.

元の言語英語
ページ(範囲)713-716
ページ数4
ジャーナルPancreatology
15
発行部数6
DOI
出版物ステータス出版済み - 1 1 2015

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Bile Duct Neoplasms
Pancreatic Neoplasms
Pancreatectomy
Mutation
Liver

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

これを引用

GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual : A case report. / Date, Kenjiro; Takao, Ohtsuka; Fujimoto, Takaaki; Gotoh, Yoshitaka; Nakashima, Yohei; Kimura, Hideyo; Matsunaga, Taketo; Mori, Yasuhisa; Mochidome, Naoki; Miyazaki, Tetsuyuki; Oda, Yoshinao; Tanaka, Masao; Nakamura, Masafumi.

:: Pancreatology, 巻 15, 番号 6, 01.01.2015, p. 713-716.

研究成果: ジャーナルへの寄稿記事

Date, Kenjiro ; Takao, Ohtsuka ; Fujimoto, Takaaki ; Gotoh, Yoshitaka ; Nakashima, Yohei ; Kimura, Hideyo ; Matsunaga, Taketo ; Mori, Yasuhisa ; Mochidome, Naoki ; Miyazaki, Tetsuyuki ; Oda, Yoshinao ; Tanaka, Masao ; Nakamura, Masafumi. / GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual : A case report. :: Pancreatology. 2015 ; 巻 15, 番号 6. pp. 713-716.
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abstract = "Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.",
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AU - Takao, Ohtsuka

AU - Fujimoto, Takaaki

AU - Gotoh, Yoshitaka

AU - Nakashima, Yohei

AU - Kimura, Hideyo

AU - Matsunaga, Taketo

AU - Mori, Yasuhisa

AU - Mochidome, Naoki

AU - Miyazaki, Tetsuyuki

AU - Oda, Yoshinao

AU - Tanaka, Masao

AU - Nakamura, Masafumi

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