Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

Keisuke Nose, Dakrong Pissuwan, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

抄録

Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO-INS-GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO-INS-GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO-INS-GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO-INS-GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.

元の言語英語
ページ(範囲)3776-3780
ページ数5
ジャーナルNanoscale
4
発行部数12
DOI
出版物ステータス出版済み - 6 12 2012

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Insulin
Medical problems
Nanorods
Gold
Oils
Irradiation
Skin
Infrared radiation
Surface-Active Agents
Glucose
Blood Glucose
Surface active agents
Blood

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

これを引用

Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice. / Nose, Keisuke; Pissuwan, Dakrong; Goto, Masahiro; Katayama, Yoshiki; Niidome, Takuro.

:: Nanoscale, 巻 4, 番号 12, 12.06.2012, p. 3776-3780.

研究成果: ジャーナルへの寄稿記事

Nose, Keisuke ; Pissuwan, Dakrong ; Goto, Masahiro ; Katayama, Yoshiki ; Niidome, Takuro. / Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice. :: Nanoscale. 2012 ; 巻 4, 番号 12. pp. 3776-3780.
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