Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

Hitomi Higuchi, Shota Yamamoto, Soichiro Ushio, Takehiro Kawashiri, Nobuaki Egashira

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.

本文言語英語
ページ(範囲)196-199
ページ数4
ジャーナルJournal of Pharmacological Sciences
129
3
DOI
出版ステータス出版済み - 11 1 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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