Grand Total EEG score can differentiate Parkinson's disease from Parkinson-related disorders

Ela Austria Barcelon, Takahiko Mukaino, Jun Yokoyama, Taira Uehara, Katsuya Ogata, Jun ichi Kira, Shozo Tobimatsu

研究成果: ジャーナルへの寄稿記事

抄録

Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well as idiopathic and vascular Parkinson's disease. Purpose: To study whether a semi-quantitative EEG analysis can aid in distinguishing idiopathic Parkinson's disease (IPD) from atypical parkinsonian disorders (APDs), and furthermore, whether it can help to distinguish between APDs. Materials and Methods: A comprehensive retrospective review of charts was performed to include patients with parkinsonian disorders who had at least one EEG recording available. A modified grand total EEG (GTE) score evaluating the posterior background activity, and diffuse and focal slow wave activities was used in further analyses. Results: We analyzed data from 76 patients with a final diagnosis of either IPD, probable corticobasal degeneration (CBD), multiple system atrophy (MSA), or progressive supra-nuclear palsy (PSP). IPD patients had the lowest mean GTE score, followed those with CBD or MSA, while PSP patients scored the highest. However, none of these differences were statistically significant. A GTE score of ≤9 distinguished IPD patients from those with APD (p < 0.01) with a sensitivity of 100% and a specificity of 33.3%. Conclusion: The modified GTE score can distinguish patients with IPD from those with CBD, PSP or MSA at a cut-off score of 9 with excellent sensitivity but poor specificity. However, this score is not able to distinguish a particular form of APD from other forms of the disorder.

元の言語英語
記事番号398
ジャーナルFrontiers in Neurology
10
発行部数APR
DOI
出版物ステータス出版済み - 1 1 2019

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Parkinson Disease
Electroencephalography
Parkinsonian Disorders
Multiple System Atrophy
Paralysis
Vascular Diseases
Dementia
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Grand Total EEG score can differentiate Parkinson's disease from Parkinson-related disorders. / Barcelon, Ela Austria; Mukaino, Takahiko; Yokoyama, Jun; Uehara, Taira; Ogata, Katsuya; Kira, Jun ichi; Tobimatsu, Shozo.

:: Frontiers in Neurology, 巻 10, 番号 APR, 398, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

Barcelon, Ela Austria ; Mukaino, Takahiko ; Yokoyama, Jun ; Uehara, Taira ; Ogata, Katsuya ; Kira, Jun ichi ; Tobimatsu, Shozo. / Grand Total EEG score can differentiate Parkinson's disease from Parkinson-related disorders. :: Frontiers in Neurology. 2019 ; 巻 10, 番号 APR.
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abstract = "Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well as idiopathic and vascular Parkinson's disease. Purpose: To study whether a semi-quantitative EEG analysis can aid in distinguishing idiopathic Parkinson's disease (IPD) from atypical parkinsonian disorders (APDs), and furthermore, whether it can help to distinguish between APDs. Materials and Methods: A comprehensive retrospective review of charts was performed to include patients with parkinsonian disorders who had at least one EEG recording available. A modified grand total EEG (GTE) score evaluating the posterior background activity, and diffuse and focal slow wave activities was used in further analyses. Results: We analyzed data from 76 patients with a final diagnosis of either IPD, probable corticobasal degeneration (CBD), multiple system atrophy (MSA), or progressive supra-nuclear palsy (PSP). IPD patients had the lowest mean GTE score, followed those with CBD or MSA, while PSP patients scored the highest. However, none of these differences were statistically significant. A GTE score of ≤9 distinguished IPD patients from those with APD (p < 0.01) with a sensitivity of 100{\%} and a specificity of 33.3{\%}. Conclusion: The modified GTE score can distinguish patients with IPD from those with CBD, PSP or MSA at a cut-off score of 9 with excellent sensitivity but poor specificity. However, this score is not able to distinguish a particular form of APD from other forms of the disorder.",
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AU - Barcelon, Ela Austria

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AU - Ogata, Katsuya

AU - Kira, Jun ichi

AU - Tobimatsu, Shozo

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N2 - Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well as idiopathic and vascular Parkinson's disease. Purpose: To study whether a semi-quantitative EEG analysis can aid in distinguishing idiopathic Parkinson's disease (IPD) from atypical parkinsonian disorders (APDs), and furthermore, whether it can help to distinguish between APDs. Materials and Methods: A comprehensive retrospective review of charts was performed to include patients with parkinsonian disorders who had at least one EEG recording available. A modified grand total EEG (GTE) score evaluating the posterior background activity, and diffuse and focal slow wave activities was used in further analyses. Results: We analyzed data from 76 patients with a final diagnosis of either IPD, probable corticobasal degeneration (CBD), multiple system atrophy (MSA), or progressive supra-nuclear palsy (PSP). IPD patients had the lowest mean GTE score, followed those with CBD or MSA, while PSP patients scored the highest. However, none of these differences were statistically significant. A GTE score of ≤9 distinguished IPD patients from those with APD (p < 0.01) with a sensitivity of 100% and a specificity of 33.3%. Conclusion: The modified GTE score can distinguish patients with IPD from those with CBD, PSP or MSA at a cut-off score of 9 with excellent sensitivity but poor specificity. However, this score is not able to distinguish a particular form of APD from other forms of the disorder.

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