Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 ​μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

本文言語英語
論文番号100247
ジャーナルMaterials Today Bio
14
DOI
出版ステータス出版済み - 3月 2022

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学
  • 分子生物学
  • 細胞生物学

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