抄録
Interleukin (IL)-15 plays an important role in the survival of human natural killer (NK) cells. We investigated IL-2/15 signaling in NK cell neoplasms from five patients and in five cell lines (NK-92, KHYG-1, SNK-6, HANK1 and MOTN-1) compared to mature peripheral NK cells from 10 healthy subjects. Apoptosis of NK cell lines was prevented by addition of IL-15 in vitro. Blocking IL-2/15Rβ on IL-2-stimulated NK-92 cells resulted in reduced expression of Bcl-X L and phosphorylated Stat5, which paralleled early apoptosis without altering Bcl-2 expression. These data add IL-2/15Rβ to the list of factors important for the survival of NK cell neoplasms.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 1023-1031 |
| ページ数 | 9 |
| ジャーナル | Leukemia Research |
| 巻 | 28 |
| 号 | 10 |
| DOI | |
| 出版ステータス | 出版済み - 10 2004 |
All Science Journal Classification (ASJC) codes
- 血液学
- 腫瘍学
- 癌研究
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
