抄録
Interleukin (IL)-15 plays an important role in the survival of human natural killer (NK) cells. We investigated IL-2/15 signaling in NK cell neoplasms from five patients and in five cell lines (NK-92, KHYG-1, SNK-6, HANK1 and MOTN-1) compared to mature peripheral NK cells from 10 healthy subjects. Apoptosis of NK cell lines was prevented by addition of IL-15 in vitro. Blocking IL-2/15Rβ on IL-2-stimulated NK-92 cells resulted in reduced expression of Bcl-X L and phosphorylated Stat5, which paralleled early apoptosis without altering Bcl-2 expression. These data add IL-2/15Rβ to the list of factors important for the survival of NK cell neoplasms.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1023-1031 |
ページ数 | 9 |
ジャーナル | Leukemia Research |
巻 | 28 |
号 | 10 |
DOI | |
出版ステータス | 出版済み - 10月 2004 |
!!!All Science Journal Classification (ASJC) codes
- 血液学
- 腫瘍学
- 癌研究