Growth based morphogenesis of vertebrate limb bud

Yoshihiro Morishita, Yoh Iwasa

研究成果: ジャーナルへの寄稿学術誌査読

29 被引用数 (Scopus)


Many genes and their regulatory relationships are involved in developmental phenomena. However, by chemical information alone, we cannot fully understand changing organ morphologies through tissue growth because deformation and growth of the organ are essentially mechanical processes. Here, we develop a mathematical model to describe the change of organ morphologies through cell proliferation. Our basic idea is that the proper specification of localized volume source (e.g., cell proliferation) is able to guide organ morphogenesis, and that the specification is given by chemical gradients. We call this idea "growth-based morphogenesis." We find that this morphogenetic mechanism works if the tissue is elastic for small deformation and plastic for large deformation. To illustrate our concept, we study the development of vertebrate limb buds, in which a limb bud protrudes from a flat lateral plate and extends distally in a self-organized manner. We show how the proportion of limb bud shape depends on different parameters and also show the conditions needed for normal morphogenesis, which can explain abnormal morphology of some mutants. We believe that the ideas shown in the present paper are useful for the morphogenesis of other organs.

ジャーナルBulletin of Mathematical Biology
出版ステータス出版済み - 10月 1 2008

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 計算理論と計算数学
  • 数学 (全般)
  • 薬理学
  • 免疫学
  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • 環境科学(全般)


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