Guest-induced conformational change of β-cyclodextrin capped with an environmentally sensitive chromophore

Kahee Fujita, Tadashi Ueda, Taiji Imoto, Iwao Tabushi, Namiko Toh, Toshitaka Koga

研究成果: Contribution to journalArticle査読

44 被引用数 (Scopus)

抄録

A capped cyclodextrin, 6-deoxy-6-(p-hydroxy-m-nitrophenacylthio)-β-cyclodextrin, was prepared in order to detect any conformational change of the host upon the guest binding. The association constant between the cyclodextrin and 1-adamantanecarboxylate, cyclohexanecarboxylate, p-methylbenzoate, 3,3-dimethylbutyrate, or 2,2-dimethylpropionate was enhanced 20, 5.3, 3.7, 2.3, or 2.0 times, respectively, by chromophore capping. The changes in the electronic, NMR, and circular dichroism spectra as well as pKa of this cyclodextrin upon binding of the guest strongly indicate a conformational change around the chromophoric moiety of the cyclodextrin.

本文言語英語
ページ(範囲)72-84
ページ数13
ジャーナルBioorganic Chemistry
11
1
DOI
出版ステータス出版済み - 3 1982

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 創薬
  • 有機化学

フィンガープリント

「Guest-induced conformational change of β-cyclodextrin capped with an environmentally sensitive chromophore」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル