Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities

Toshihiro Houdai, Shigeru Matsuoka, Nagy Morsy, Nobuaki Matsumori, Masayuki Satake, Michio Murata

研究成果: ジャーナルへの寄稿学術誌査読

56 被引用数 (Scopus)

抄録

Amphidinols are a unique dinoflagellate metabolite with potent antifungal activity. We examined membrane permeabilizing action by amphidinol analogues with structural variations in polyhydroxy and polyene moieties. Consequently, the polyene and polyhydroxy moieties turned out to play important roles in binding to lipid bilayer membrane and in forming ion-permeable pore/lesion across membrane, respectively. NMR-constrained modeling experiments have revealed for the fist time that amphidinols in membrane generally take a hairpin configuration, which plausibly accounts for their potent antifungal and other membrane permeabilizing activities.

本文言語英語
ページ(範囲)2795-2802
ページ数8
ジャーナルTetrahedron
61
11
DOI
出版ステータス出版済み - 3月 14 2005
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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