Haptotactic migration of pancreatic cancer cells induced by bioactive components in bovine liver extract

Hiroshi Ito, Masaru Miyazaki, Fusanori Nishimura, Nobuyuki Nakajima

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Background and Objectives: Migration into subendothelial tissue in remote organ by cancer cells are crucial events for organ-specific metastasis, including liver metastasis. This study aims to investigate the chemoattractive ingredients in liver extract, which induce migration of liver metastatic cancer cells. Methods: Cell migrations of SU.86.86 cells, human pancreatic cancer cells raised from liver metastasis, toward the bovine liver extract were studied by chemotaxis or haptotaxis assay. Bovine liver extract was partially purified by chromatographic or gel elutriation method. Results: The soluble fraction of the liver extract did not induce chemotactic migration of SU.86.86 cells. However, the insoluble fraction induced a remarkable haptotactic migratory response. C18 column unbound insoluble fractions eluted from SDS-PAGE induced chemotactic migration of SU.86.86 cells. Conclusion: Such bioactive components in liver extract may play an important role in the development of liver metastasis.

本文言語英語
ページ(範囲)153-158
ページ数6
ジャーナルJournal of Surgical Oncology
68
3
DOI
出版ステータス出版済み - 7 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

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