Hashimoto’s thyroiditis and HLA in japanese

Koji Honda, Hajime Tamai, Tetsuya Morita, Kanji Kuma, Yasuharu Nishimura, Takehiko Sasazuki

研究成果: ジャーナルへの寄稿学術誌査読

45 被引用数 (Scopus)


To investigate genetic factors involved in the pathogenesis of Hashimoto’s thyroiditis (HT; goitrous autoimmune thyroiditis), HLA class I and class II antigens were analyzed in both seropositive HT (99 patients) and seronegative HT (43 patients). The frequency of HLA-DRw53 antigen was increased significantly in both seropositive HT (antigen frequency, 0.83; relative risk, 3.33; P < 0.0002; corrected P < 0.001) and seronegative HT (antigen frequency, 0.81; relative risk, 3.02; P < 0.01; corrected P < 0.05). The etiological fraction values for HLA-DRw53 in seropositive HT and seronegative HT were 0.58 and 0.54, respectively. An increased frequency of HLA-DQw4 and a decreased frequency of HLA-DQwl were observed in patients with seronegative HT. These data suggest that susceptibility to HT is primarily associated with HLA-DRw53 and that HLA-DQ alleles may control the production of autoantibodies to the thyroid gland. The mode of inheritance of disease susceptibility for HT (controlled by a major gene in linkage disequilibrium with HLA-DRw53) was investigated by the method of Thomson and Bodmer, and it was suggested that disease susceptibility was inherited in a dominant manner.

ジャーナルJournal of Clinical Endocrinology and Metabolism
出版ステータス出版済み - 1月 1 1989

!!!All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学


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