Head and neck cancer antigens recognized by the humoral immune system

Mikio Monji, Satoru Senju, Tetsuya Nakatsura, Kazuhiro Yamada, Motohiro Sawatsubashi, Akira Inokuchi, Yasuharu Nishimura

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Head and neck cancer in advanced stages are difficult to treat. Therefore development of new treatment modalities and preventive measures are required. We now report the identification of human head and neck cancer antigens recognized by the humoral immune system. We used the serological analysis of recombinant cDNA expression libraries (SEREX) approach. cDNA libraries from cell lines of squamous cell carcinoma of head and neck (SCCHN) and a normal testicle tissue were screened using sera from six allogeneic SCCHN patients. Total 28 positive clones belonging to 19 different genes were identified including 12 known genes and 7 unknown ones. Expression analysis on 13 normal tissues and 13 cancer tissues using reverse transcription-PCR (RT-PCR) revealed eight ubiquitously expressed genes nine of which were expressed preferentially in cancer tissues and two cancer/testis antigens. These antigens we defined may be pertinent candidate antigens for future cancer-diagnosis and related immunotherapy.

元の言語英語
ページ(範囲)734-741
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
294
発行部数3
DOI
出版物ステータス出版済み - 1 1 2002

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Monji, M., Senju, S., Nakatsura, T., Yamada, K., Sawatsubashi, M., Inokuchi, A., & Nishimura, Y. (2002). Head and neck cancer antigens recognized by the humoral immune system. Biochemical and Biophysical Research Communications, 294(3), 734-741. https://doi.org/10.1016/S0006-291X(02)00543-0