Healing of two-wall intra-bony defects treated with a novel EMD-liquid—A pre-clinical study in monkeys

Yoshinori Shirakata, Richard J. Miron, Yukiya Shinohara, Toshiaki Nakamura, Kotaro Sena, Naoto Horai, Dieter D. Bosshardt, Kazuyuki Noguchi, Anton Sculean

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Aim: To investigate the effect of a novel enamel matrix derivative formulation (EMD-liquid or Osteogain) combined with an absorbable collagen sponge (ACS) on periodontal wound healing in intra-bony defects in monkeys. Materials and Methods: Chronic two-wall intra-bony defects were created at the distal aspect of eight teeth in three monkeys (Macaca fascicularis). The 24 defects were randomly assigned to one of the following treatments: (i) open flap debridement (OFD) + ACS alone, (ii) OFD + Emdogain + ACS (Emdogain/ACS), (iii) OFD + Osteogain + ACS (Osteogain/ACS) or (iv) OFD alone. At 4 months, the animals were euthanized for histologic evaluation. Results: Osteogain/ACS resulted in more consistent formation of cementum, periodontal ligament and bone with limited epithelial proliferation compared to OFD alone, Emdogain/ACS and OFD + ACS. Among the four treatment groups, the Osteogain/ACS group demonstrated the highest amount of regenerated tissues. However, complete periodontal regeneration was not observed in any of the defects in the four groups. Conclusions: The present findings indicate that in two-wall intra-bony defects, reconstructive surgery with Osteogain/ACS appears to be a promising novel approach for facilitating periodontal wound healing/regeneration, thus warranting further clinical testing.

本文言語英語
ページ(範囲)1264-1273
ページ数10
ジャーナルJournal of Clinical Periodontology
44
12
DOI
出版ステータス出版済み - 12 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • Periodontics

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