Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles

Masaki Yamaguchi, Akira Ito, Akihiko Ono, Kawabe Yoshinori, Masamichi Kamihira

研究成果: Contribution to journalArticle査読

31 被引用数 (Scopus)

抄録

By combining synthetic biology with nanotechnology, we demonstrate remote controlled gene expression using a magnetic field. Magnetite nanoparticles, which generate heat under an alternating magnetic field, have been developed to label cells. Magnetite nanoparticles and heat-induced therapeutic genes were introduced into tumor xenografts. The magnetically triggered gene expression resulted in tumor growth inhibition. This system shows great potential for controlling target gene expression in a space and time selective manner and may be used for remote control of cell functions via gene expression.

本文言語英語
ページ(範囲)273-279
ページ数7
ジャーナルACS Synthetic Biology
3
5
DOI
出版ステータス出版済み - 5 16 2014

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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