抄録
With global warming, heat stress is becoming a pressing concern worldwide. In chickens, heat stress reduces food intake and growth, and increases body temperature and stress responses. Although it is believed that young chicks do not experience heat stress as they need a higher ambient temperature to survive, our series of studies in young chicks showed that they are sensitive to heat stress. This review summarizes current knowledge on amino acid metabolisms during heat stress, with special emphasis on the hypothermic functions of L-citrulline (L-Cit) and L-leucine (L-Leu), and the functions of neuropeptide Y (NPY) in terms of body temperature and heat stress regulation in chicks. Amino acid metabolism is severely affected by heat stress. For example, prolonged heat stress reduces plasma L-Cit in chicks and L-Leu in the brain and liver of embryos. L-Cit and L-Leu supplementation affords thermotolerance in young chicks. NPY expression is increased in the brains of heat-exposed chicks. NPY has a hypothermic action under control thermoneutral temperature and heat stress in chicks. The NPY-sub-receptor Y5 is a partial mediator of the hypothermic action of NPY. Further, NPY stimulates brain dopamine concentrations and acts as an anti-stress agent in heat-exposed fasted, but not fed chicks. In conclusion, young chicks can serve as a model animal for the study of heat stress in chickens. L-Cit, L-Leu, and NPY were identified as biomarkers of heat stress, with the potential to afford thermotolerance in chicks.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1-11 |
| ページ数 | 11 |
| ジャーナル | Journal of Poultry Science |
| 巻 | 56 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2019 |
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All Science Journal Classification (ASJC) codes
- Animal Science and Zoology
これを引用
Heat stress biomarker amino acids and neuropeptide afford thermotolerance in chicks. / Chowdhury, Vishwajit S.
：: Journal of Poultry Science, 巻 56, 番号 1, 01.01.2019, p. 1-11.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Heat stress biomarker amino acids and neuropeptide afford thermotolerance in chicks
AU - Chowdhury, Vishwajit S.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - With global warming, heat stress is becoming a pressing concern worldwide. In chickens, heat stress reduces food intake and growth, and increases body temperature and stress responses. Although it is believed that young chicks do not experience heat stress as they need a higher ambient temperature to survive, our series of studies in young chicks showed that they are sensitive to heat stress. This review summarizes current knowledge on amino acid metabolisms during heat stress, with special emphasis on the hypothermic functions of L-citrulline (L-Cit) and L-leucine (L-Leu), and the functions of neuropeptide Y (NPY) in terms of body temperature and heat stress regulation in chicks. Amino acid metabolism is severely affected by heat stress. For example, prolonged heat stress reduces plasma L-Cit in chicks and L-Leu in the brain and liver of embryos. L-Cit and L-Leu supplementation affords thermotolerance in young chicks. NPY expression is increased in the brains of heat-exposed chicks. NPY has a hypothermic action under control thermoneutral temperature and heat stress in chicks. The NPY-sub-receptor Y5 is a partial mediator of the hypothermic action of NPY. Further, NPY stimulates brain dopamine concentrations and acts as an anti-stress agent in heat-exposed fasted, but not fed chicks. In conclusion, young chicks can serve as a model animal for the study of heat stress in chickens. L-Cit, L-Leu, and NPY were identified as biomarkers of heat stress, with the potential to afford thermotolerance in chicks.
AB - With global warming, heat stress is becoming a pressing concern worldwide. In chickens, heat stress reduces food intake and growth, and increases body temperature and stress responses. Although it is believed that young chicks do not experience heat stress as they need a higher ambient temperature to survive, our series of studies in young chicks showed that they are sensitive to heat stress. This review summarizes current knowledge on amino acid metabolisms during heat stress, with special emphasis on the hypothermic functions of L-citrulline (L-Cit) and L-leucine (L-Leu), and the functions of neuropeptide Y (NPY) in terms of body temperature and heat stress regulation in chicks. Amino acid metabolism is severely affected by heat stress. For example, prolonged heat stress reduces plasma L-Cit in chicks and L-Leu in the brain and liver of embryos. L-Cit and L-Leu supplementation affords thermotolerance in young chicks. NPY expression is increased in the brains of heat-exposed chicks. NPY has a hypothermic action under control thermoneutral temperature and heat stress in chicks. The NPY-sub-receptor Y5 is a partial mediator of the hypothermic action of NPY. Further, NPY stimulates brain dopamine concentrations and acts as an anti-stress agent in heat-exposed fasted, but not fed chicks. In conclusion, young chicks can serve as a model animal for the study of heat stress in chickens. L-Cit, L-Leu, and NPY were identified as biomarkers of heat stress, with the potential to afford thermotolerance in chicks.
UR - http://www.scopus.com/inward/record.url?scp=85062099045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062099045&partnerID=8YFLogxK
U2 - 10.2141/jpsa.0180024
DO - 10.2141/jpsa.0180024
M3 - Review article
AN - SCOPUS:85062099045
VL - 56
SP - 1
EP - 11
JO - Journal of Poultry Science
JF - Journal of Poultry Science
SN - 1346-7395
IS - 1
ER -