Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer

Hideya Onishi, Mitsuo Katano

研究成果: Contribution to journalArticle査読

56 被引用数 (Scopus)

抄録

Pancreatic cancer is one of the most aggressive and difficult cancers to treat. Despite numerous research efforts, limited success has been achieved in the therapeutic management of patients with this disease. In the current review, we focus on one component of morphogenesis signaling, Hedgehog (Hh), with the aim of developing novel, effective therapies for the treatment of pancreatic cancer. Hh signaling contributes to the induction of a malignant phenotype in pancreatic cancer and is responsible for maintaining pancreatic cancer stem cells. In addition, we propose a novel concept linking Hh signaling and tumor hypoxic conditions, and discuss the effects of Hh inhibitors in clinical trials. The Hh signaling pathway may represent a potential therapeutic target for patients with refractory pancreatic cancer.

本文言語英語
ページ(範囲)2335-2342
ページ数8
ジャーナルWorld Journal of Gastroenterology
20
9
DOI
出版ステータス出版済み - 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 消化器病学

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