Hedgehog signaling pathway as a therapeutic target in various types of cancer

Hideya Ohnishi, Mitsuo Katano

研究成果: ジャーナルへの寄稿評論記事

68 引用 (Scopus)

抄録

Hedgehog (Hh) signaling is an important factor in growth and patterning during embryonic development. A mutation in Patched, Smoothened or Gli1, which regulate the Hh signaling pathway, might lead to the onset of glioblastoma, basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. Recently, Hh signaling has been reported to be activated in a ligand-dependent manner, contributing to carcinogenesis and cancer progression. Hedgehog signaling is reactivated in various types of cancer, and this contributes to cancer progression by facilitating proliferation, invasion and cell survival. Moreover, Hh signaling is associated with several other signaling pathways that contribute to cancer progression. These observations indicate that controlling Hh signaling might become a target for novel molecular targeting therapy.

元の言語英語
ページ(範囲)1756-1760
ページ数5
ジャーナルCancer Science
102
発行部数10
DOI
出版物ステータス出版済み - 10 1 2011

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Neoplasms
Medulloblastoma
Rhabdomyosarcoma
Basal Cell Carcinoma
Therapeutics
Glioblastoma
Embryonic Development
Cell Survival
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Ligands
Mutation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Hedgehog signaling pathway as a therapeutic target in various types of cancer. / Ohnishi, Hideya; Katano, Mitsuo.

:: Cancer Science, 巻 102, 番号 10, 01.10.2011, p. 1756-1760.

研究成果: ジャーナルへの寄稿評論記事

Ohnishi, Hideya ; Katano, Mitsuo. / Hedgehog signaling pathway as a therapeutic target in various types of cancer. :: Cancer Science. 2011 ; 巻 102, 番号 10. pp. 1756-1760.
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