Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes

Hideya Ohnishi, Akiko Fujimura, Yasuhiro Oyama, Akio Yamasaki, Akira Imaizumi, Makoto Kawamoto, Mitsuo Katano, Masayo Umebayashi, Takashi Morisaki

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

We investigated whether hypoxia-induced activation of Hh signaling contributes to PDL-1 expression in cancer and whether it affects the anti-tumor function of activated lymphocytes. Hypoxia augmented PDL-1 expression and inhibition of Hh signaling reduced PDL-1 expression under hypoxia. When activated lymphocytes were cocultured with cancers treated with a Hh inhibitor, activated lymphocyte cell numbers increased under hypoxia. In contrast, this increase was abrogated when cancer cells were treated with a PDL-1 neutralizing antibody. These results suggest that Hh signaling is one of regulatory pathways of PDL-1 expression under hypoxia and that inhibiting Hh signaling may induce lymphocyte anti-tumor activity.

元の言語英語
ページ(範囲)199-204
ページ数6
ジャーナルCellular Immunology
310
DOI
出版物ステータス出版済み - 12 1 2016

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Lymphocytes
Neoplasms
Lymphocyte Count
Neutralizing Antibodies
Cell Count
Hypoxia

All Science Journal Classification (ASJC) codes

  • Immunology

これを引用

Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes. / Ohnishi, Hideya; Fujimura, Akiko; Oyama, Yasuhiro; Yamasaki, Akio; Imaizumi, Akira; Kawamoto, Makoto; Katano, Mitsuo; Umebayashi, Masayo; Morisaki, Takashi.

:: Cellular Immunology, 巻 310, 01.12.2016, p. 199-204.

研究成果: ジャーナルへの寄稿記事

Ohnishi, H, Fujimura, A, Oyama, Y, Yamasaki, A, Imaizumi, A, Kawamoto, M, Katano, M, Umebayashi, M & Morisaki, T 2016, 'Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes', Cellular Immunology, 巻. 310, pp. 199-204. https://doi.org/10.1016/j.cellimm.2016.08.003
Ohnishi, Hideya ; Fujimura, Akiko ; Oyama, Yasuhiro ; Yamasaki, Akio ; Imaizumi, Akira ; Kawamoto, Makoto ; Katano, Mitsuo ; Umebayashi, Masayo ; Morisaki, Takashi. / Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes. :: Cellular Immunology. 2016 ; 巻 310. pp. 199-204.
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abstract = "We investigated whether hypoxia-induced activation of Hh signaling contributes to PDL-1 expression in cancer and whether it affects the anti-tumor function of activated lymphocytes. Hypoxia augmented PDL-1 expression and inhibition of Hh signaling reduced PDL-1 expression under hypoxia. When activated lymphocytes were cocultured with cancers treated with a Hh inhibitor, activated lymphocyte cell numbers increased under hypoxia. In contrast, this increase was abrogated when cancer cells were treated with a PDL-1 neutralizing antibody. These results suggest that Hh signaling is one of regulatory pathways of PDL-1 expression under hypoxia and that inhibiting Hh signaling may induce lymphocyte anti-tumor activity.",
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AU - Ohnishi, Hideya

AU - Fujimura, Akiko

AU - Oyama, Yasuhiro

AU - Yamasaki, Akio

AU - Imaizumi, Akira

AU - Kawamoto, Makoto

AU - Katano, Mitsuo

AU - Umebayashi, Masayo

AU - Morisaki, Takashi

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AB - We investigated whether hypoxia-induced activation of Hh signaling contributes to PDL-1 expression in cancer and whether it affects the anti-tumor function of activated lymphocytes. Hypoxia augmented PDL-1 expression and inhibition of Hh signaling reduced PDL-1 expression under hypoxia. When activated lymphocytes were cocultured with cancers treated with a Hh inhibitor, activated lymphocyte cell numbers increased under hypoxia. In contrast, this increase was abrogated when cancer cells were treated with a PDL-1 neutralizing antibody. These results suggest that Hh signaling is one of regulatory pathways of PDL-1 expression under hypoxia and that inhibiting Hh signaling may induce lymphocyte anti-tumor activity.

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