Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes

Hideya Onishi, Akiko Fujimura, Yasuhiro Oyama, Akio Yamasaki, Akira Imaizumi, Makoto Kawamoto, Mitsuo Katano, Masayo Umebayashi, Takashi Morisaki

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

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We investigated whether hypoxia-induced activation of Hh signaling contributes to PDL-1 expression in cancer and whether it affects the anti-tumor function of activated lymphocytes. Hypoxia augmented PDL-1 expression and inhibition of Hh signaling reduced PDL-1 expression under hypoxia. When activated lymphocytes were cocultured with cancers treated with a Hh inhibitor, activated lymphocyte cell numbers increased under hypoxia. In contrast, this increase was abrogated when cancer cells were treated with a PDL-1 neutralizing antibody. These results suggest that Hh signaling is one of regulatory pathways of PDL-1 expression under hypoxia and that inhibiting Hh signaling may induce lymphocyte anti-tumor activity.

元の言語英語
ページ(範囲)199-204
ページ数6
ジャーナルCellular Immunology
310
DOI
出版物ステータス出版済み - 12 1 2016

All Science Journal Classification (ASJC) codes

  • Immunology

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    Onishi, H., Fujimura, A., Oyama, Y., Yamasaki, A., Imaizumi, A., Kawamoto, M., Katano, M., Umebayashi, M., & Morisaki, T. (2016). Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytes. Cellular Immunology, 310, 199-204. https://doi.org/10.1016/j.cellimm.2016.08.003