Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects

Hiroki Satoh, Yasuaki Saijo, Eiji Yoshioka, Hiroyuki Tsutsui

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

抄録

Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95% CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.

元の言語英語
ページ(範囲)1041-1048
ページ数8
ジャーナルJournal of atherosclerosis and thrombosis
17
発行部数10
DOI
出版物ステータス出版済み - 1 1 2010
外部発表Yes

Fingerprint

Helicobacter Infections
HDL Lipoproteins
LDL Lipoproteins
Helicobacter pylori
LDL Cholesterol
HDL Cholesterol
Lipids
Antibodies
Confidence Intervals
Cardiovascular Diseases
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

これを引用

Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects. / Satoh, Hiroki; Saijo, Yasuaki; Yoshioka, Eiji; Tsutsui, Hiroyuki.

:: Journal of atherosclerosis and thrombosis, 巻 17, 番号 10, 01.01.2010, p. 1041-1048.

研究成果: ジャーナルへの寄稿記事

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abstract = "Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8{\%} and 39.6{\%} in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95{\%} CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95{\%} CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.",
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N2 - Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95% CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.

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