Hematopoietic developmental pathways: On cellular basis

H. Iwasaki, K. Akashi

研究成果: Contribution to journalReview article査読

70 被引用数 (Scopus)

抄録

To elucidate the molecular mechanisms underlying normal and malignant hematopoietic development, it is critical to identify developmental intermediates for each lineage downstream of hematopoietic stem cells. Recent advances in prospective isolation of hematopoietic stem and progenitor cells, and efficient xenogeneic transplantation systems have provided a detailed developmental map in both mouse and human hematopoiesis, demonstrating that surface phenotypes of mouse stem-progenitor cells and their human counterparts are considerably different. Here, we summarize the phenotype and functional properties and their differences of hematopoietic stem and progenitor cell populations between mouse and human.

本文言語英語
ページ(範囲)6687-6696
ページ数10
ジャーナルOncogene
26
47
DOI
出版ステータス出版済み - 10 15 2007

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学
  • 癌研究

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