Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis

研究成果: ジャーナルへの寄稿評論記事

9 引用 (Scopus)

抄録

Human malignancies develop through the multistep acquisition of critical somatic mutations during the clinical course. Regarding hematological malignancies, recent novel findings have indicated that hematopoietic stem cells (HSCs), which have the potential to self-renew and differentiate into multilineage hematopoietic cells, are an important cellular target for the accumulation of critical somatic mutations and play a central role in myeloid malignancy development. In contrast to myeloid malignancies, mature lymphoid malignancies, such as chronic lymphocytic leukemia (CLL), are considered to directly originate from differentiated mature lymphocytes; however, we previously reported that the propensity to generate clonal B cells had already been acquired at the HSC stage in CLL patients. Similarly, HSC involvement has been reported in the pathogenesis of mature T cell lymphomas. These studies indicate that, in mature lymphoid, if not all, malignancies, HSCs should be considered as the critical cellular target in the oncogenic process. The prevalence of these hematological malignancies dramatically increases with age, and the effect of aging HSCs should thus be taken into account when investigating the stepwise malignant transformation process of these age-associated malignancies.

元の言語英語
ページ(範囲)335-340
ページ数6
ジャーナルInternational journal of hematology
100
発行部数4
DOI
出版物ステータス出版済み - 10 9 2014

Fingerprint

Cell Aging
B-Cell Chronic Lymphocytic Leukemia
Hematopoietic Stem Cells
Neoplasms
Hematologic Neoplasms
Mutation
T-Cell Lymphoma
B-Lymphocytes
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Medicine(all)

これを引用

Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis. / Kikushige, Yoshikane; Miyamoto, Toshihiro.

:: International journal of hematology, 巻 100, 番号 4, 09.10.2014, p. 335-340.

研究成果: ジャーナルへの寄稿評論記事

@article{1fec5aea62dd419cae474c70ecfde702,
title = "Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis",
abstract = "Human malignancies develop through the multistep acquisition of critical somatic mutations during the clinical course. Regarding hematological malignancies, recent novel findings have indicated that hematopoietic stem cells (HSCs), which have the potential to self-renew and differentiate into multilineage hematopoietic cells, are an important cellular target for the accumulation of critical somatic mutations and play a central role in myeloid malignancy development. In contrast to myeloid malignancies, mature lymphoid malignancies, such as chronic lymphocytic leukemia (CLL), are considered to directly originate from differentiated mature lymphocytes; however, we previously reported that the propensity to generate clonal B cells had already been acquired at the HSC stage in CLL patients. Similarly, HSC involvement has been reported in the pathogenesis of mature T cell lymphomas. These studies indicate that, in mature lymphoid, if not all, malignancies, HSCs should be considered as the critical cellular target in the oncogenic process. The prevalence of these hematological malignancies dramatically increases with age, and the effect of aging HSCs should thus be taken into account when investigating the stepwise malignant transformation process of these age-associated malignancies.",
author = "Yoshikane Kikushige and Toshihiro Miyamoto",
year = "2014",
month = "10",
day = "9",
doi = "10.1007/s12185-014-1651-6",
language = "English",
volume = "100",
pages = "335--340",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis

AU - Kikushige, Yoshikane

AU - Miyamoto, Toshihiro

PY - 2014/10/9

Y1 - 2014/10/9

N2 - Human malignancies develop through the multistep acquisition of critical somatic mutations during the clinical course. Regarding hematological malignancies, recent novel findings have indicated that hematopoietic stem cells (HSCs), which have the potential to self-renew and differentiate into multilineage hematopoietic cells, are an important cellular target for the accumulation of critical somatic mutations and play a central role in myeloid malignancy development. In contrast to myeloid malignancies, mature lymphoid malignancies, such as chronic lymphocytic leukemia (CLL), are considered to directly originate from differentiated mature lymphocytes; however, we previously reported that the propensity to generate clonal B cells had already been acquired at the HSC stage in CLL patients. Similarly, HSC involvement has been reported in the pathogenesis of mature T cell lymphomas. These studies indicate that, in mature lymphoid, if not all, malignancies, HSCs should be considered as the critical cellular target in the oncogenic process. The prevalence of these hematological malignancies dramatically increases with age, and the effect of aging HSCs should thus be taken into account when investigating the stepwise malignant transformation process of these age-associated malignancies.

AB - Human malignancies develop through the multistep acquisition of critical somatic mutations during the clinical course. Regarding hematological malignancies, recent novel findings have indicated that hematopoietic stem cells (HSCs), which have the potential to self-renew and differentiate into multilineage hematopoietic cells, are an important cellular target for the accumulation of critical somatic mutations and play a central role in myeloid malignancy development. In contrast to myeloid malignancies, mature lymphoid malignancies, such as chronic lymphocytic leukemia (CLL), are considered to directly originate from differentiated mature lymphocytes; however, we previously reported that the propensity to generate clonal B cells had already been acquired at the HSC stage in CLL patients. Similarly, HSC involvement has been reported in the pathogenesis of mature T cell lymphomas. These studies indicate that, in mature lymphoid, if not all, malignancies, HSCs should be considered as the critical cellular target in the oncogenic process. The prevalence of these hematological malignancies dramatically increases with age, and the effect of aging HSCs should thus be taken into account when investigating the stepwise malignant transformation process of these age-associated malignancies.

UR - http://www.scopus.com/inward/record.url?scp=84927171995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927171995&partnerID=8YFLogxK

U2 - 10.1007/s12185-014-1651-6

DO - 10.1007/s12185-014-1651-6

M3 - Review article

VL - 100

SP - 335

EP - 340

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 4

ER -