Hemodynamic differences between the awake and anesthetized conditions in normal calves

Tohru Takaseya, Masako Fujiki, Akira Shiose, Hyun Il Kim, Mariko Kobayashi, Alex L. Massiello, Raymond Dessoffy, Sharif Al-Ruzzeh, Kiyotaka Fukamachi

研究成果: Contribution to journalArticle

4 引用 (Scopus)

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There is insufficient information in the literature about baseline circulatory parameters in normal calves in the anesthetized versus postoperative awake conditions under which a large volume of medical research is conducted. Eleven calves (mean body weight, 78.1 ± 14.3 kg) were implanted with a flow probe and fluid-filled pressure lines to measure cardiac output (CO), aortic (AoP), central venous (CVP), pulmonary arterial (PAP), and left atrial pressures (LAP). Systemic (SVR) and pulmonary vascular resistance (PVR) were also calculated. We obtained the above hemodynamic data (n = 11) and epicardial echocardiography (n = 7) during open-chest surgery under isoflurane anesthesia. After full recovery from surgery, animals were evaluated in the awake condition on postoperative days 6-9 using transthoracic echocardiography (n = 7) and the hemodynamic monitoring lines and probes noted (n = 11). CO, AoP, and PAP levels in the anesthetized condition were significantly lower than in the awake condition. Other hemodynamic parameters (CVP, LAP, SVR, and PVR) were not significantly different. In conclusion, data from this study quantify changes in CO, AoP, and PAP in anesthetized calves that may affect the hemodynamic response to experimental therapeutics such as new cardiac assist devices, prosthetic valves, and surgical interventions. Our study also provides baseline data for the translation of the hemodynamic data obtained in acute in vivo calf studies to that of an awake subject.

元の言語英語
ページ(範囲)225-230
ページ数6
ジャーナルJournal of Artificial Organs
15
発行部数3
DOI
出版物ステータス出版済み - 9 1 2012
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

フィンガープリント Hemodynamic differences between the awake and anesthetized conditions in normal calves' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Takaseya, T., Fujiki, M., Shiose, A., Kim, H. I., Kobayashi, M., Massiello, A. L., Dessoffy, R., Al-Ruzzeh, S., & Fukamachi, K. (2012). Hemodynamic differences between the awake and anesthetized conditions in normal calves. Journal of Artificial Organs, 15(3), 225-230. https://doi.org/10.1007/s10047-012-0636-6