Hemogenic endothelium: A vessel for blood production

Veronica I. Antas, Mohammad A. Al-Drees, Alexander J.A. Prudence, Daisuke Sugiyama, Stuart T. Fraser

    研究成果: Contribution to journalShort survey査読

    20 被引用数 (Scopus)


    Blood cell production, or hematopoiesis, is critical to the survival of the developing mammalian embryo. The origins of hematopoietic stem cells, capable of giving rise to all blood cell types, are being revealed. During embryogenesis, hematopoietic stem and progenitor cells are generated from a unique population of vascular endothelium termed hemogenic endothelial cells. These unusual endothelial cells are found in a restricted number of sites in the conceptus and within a narrow window of embryonic development. Loss of hemogenic endothelial cells through gene ablation leads to a lack of blood production and embryonic lethality. Here, we describe historical and recent observations exploring the biology of these intriguing endothelial cells and their roles in hematopoiesis both in the embryo and, possibly, in the adult. Crown

    ジャーナルInternational Journal of Biochemistry and Cell Biology
    出版ステータス出版済み - 3 2013

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 細胞生物学


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