The purpose of this study was to determine the CT and sonographic features of hepatic lymphoma developing in organ transplant recipients taking cyclosporine. The 4 patients included in the study had non-Hodgkin lymphoma. Two of the cases were primary, with no associated lymphadenopathy or extrahepatic lesions. The hepatic lymphomas were characterized by multiple low-density areas on CT scans and hypoechoic areas on sonograms. In 3 of the 4 patients, the lesions regressed after the cyclosporine dosage was reduced. We conclude that in cyclosporine-treated organ transplant recipients, hepatic lymphoma should be considered in the differential diagnosis of hepatic lesions with or without lymphadenopathy when multiple low-density lesions are shown by CT and hypoechoic lesions are shown by sonography.
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