Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy

Fujiko Mitsumoto, Murata Masayuki, Yoshifumi Kato, Kazuya Ura, Koji Takayama, Satoshi Hiramine, Hiroaki Ikezaki, Motohiro Shimizu, Kazuhiro Toyoda, Eiichi Ogawa, Shinichi Aishima, Norihiro Furusyo, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Hepatic flares occurred in two patients with HBV/HIV coinfection following the commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV DNA levels had decreased. The results of liver biopsies showed lymphocytic infiltration that was diffusely positive for CD8+ T cells in the portal areas and lobules. These findings suggested HBV-related immune reconstitution inflammatory syndrome (IRIS). The alanine aminotransferase levels of both patients gradually decreased with the continuation of ART. Because there are few reports of the liver histology of HBV-related IRIS, these cases provide a better understanding of the pathogenesis of HBV-related IRIS.

元の言語英語
ページ(範囲)2165-2170
ページ数6
ジャーナルInternal Medicine
53
発行部数18
DOI
出版物ステータス出版済み - 9 1 2014

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Immune Reconstitution Inflammatory Syndrome
Hepatitis B virus
HIV
Biopsy
Liver
Alanine Transaminase
Coinfection
Histology
RNA
T-Lymphocytes
DNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy. / Mitsumoto, Fujiko; Masayuki, Murata; Kato, Yoshifumi; Ura, Kazuya; Takayama, Koji; Hiramine, Satoshi; Ikezaki, Hiroaki; Shimizu, Motohiro; Toyoda, Kazuhiro; Ogawa, Eiichi; Aishima, Shinichi; Furusyo, Norihiro; Hayashi, Jun.

:: Internal Medicine, 巻 53, 番号 18, 01.09.2014, p. 2165-2170.

研究成果: ジャーナルへの寄稿記事

Mitsumoto, Fujiko ; Masayuki, Murata ; Kato, Yoshifumi ; Ura, Kazuya ; Takayama, Koji ; Hiramine, Satoshi ; Ikezaki, Hiroaki ; Shimizu, Motohiro ; Toyoda, Kazuhiro ; Ogawa, Eiichi ; Aishima, Shinichi ; Furusyo, Norihiro ; Hayashi, Jun. / Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy. :: Internal Medicine. 2014 ; 巻 53, 番号 18. pp. 2165-2170.
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AU - Mitsumoto, Fujiko

AU - Masayuki, Murata

AU - Kato, Yoshifumi

AU - Ura, Kazuya

AU - Takayama, Koji

AU - Hiramine, Satoshi

AU - Ikezaki, Hiroaki

AU - Shimizu, Motohiro

AU - Toyoda, Kazuhiro

AU - Ogawa, Eiichi

AU - Aishima, Shinichi

AU - Furusyo, Norihiro

AU - Hayashi, Jun

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