Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma

Joji Shimono, Hiroaki Miyoshi, Takeharu Kato, Takeshi Sugio, Kohta Miyawaki, Tomohiko Kamimura, Takuto Miyagishima, Tetsuya Eto, Yoshitaka Imaizumi, Koji Kato, Koji Nagafuji, Koichi Akashi, Masao Seto, Takanori Teshima, Koichi Ohshima

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Hepatitis C virus (HCV) is a single-stranded RNA virus that not only affects hepatocytes, by B cells as well. It is thought that HCV is involved in the onset of B-cell lymphoma. The clinicopathological characteristics of HCV-positive diffuse large B-cell lymphoma (DLBCL) and HCV-positive splenic marginal zone lymphoma (SMZL) are known, but there has been no report on HCV-positive follicular lymphoma (FL). In this study, the clinicopathological characteristics of HCV-positive FL were examined in 263 patients with FL who were classified into a HCV-positive group with HCV antibody and negative groups without one. The number of patients with HCV-positive FL and HCV-negative FL was 10 (3.8%) and 253 (96.2%), respectively. The patients with HCV-positive FL commonly had more than one region of lymphadenopathy, Ann Arbor stage III/IV, hemoglobin < 120 g/l, elevated lactate dehydrogenase level, and highrisk categorization of Follicular Lymphoma International Prognostic Index (FLIPI) than in patients with HCV-negative FL. Overall survival and progression-free survival were poorer in patients with HCV-positive FL than in those with HCV-negative FL (p < 0.0001 and 0.006, respectively). Also, multivariate analysis revealed that positive HCV antibody was a poor prognostic factor of OS. In conclusion, HCV-positive FL has unique clinical features and may have a great impact on the overall survival of affected patients.

元の言語英語
ページ(範囲)1717-1725
ページ数9
ジャーナルOncotarget
9
発行部数2
DOI
出版物ステータス出版済み - 1 1 2018

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Follicular Lymphoma
Virus Diseases
Hepacivirus
Hepatitis C Antibodies
Survival
Lymphoma, Large B-Cell, Diffuse
RNA Viruses
B-Cell Lymphoma
L-Lactate Dehydrogenase
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Oncology

これを引用

Shimono, J., Miyoshi, H., Kato, T., Sugio, T., Miyawaki, K., Kamimura, T., ... Ohshima, K. (2018). Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma. Oncotarget, 9(2), 1717-1725. https://doi.org/10.18632/oncotarget.23138

Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma. / Shimono, Joji; Miyoshi, Hiroaki; Kato, Takeharu; Sugio, Takeshi; Miyawaki, Kohta; Kamimura, Tomohiko; Miyagishima, Takuto; Eto, Tetsuya; Imaizumi, Yoshitaka; Kato, Koji; Nagafuji, Koji; Akashi, Koichi; Seto, Masao; Teshima, Takanori; Ohshima, Koichi.

:: Oncotarget, 巻 9, 番号 2, 01.01.2018, p. 1717-1725.

研究成果: ジャーナルへの寄稿記事

Shimono, J, Miyoshi, H, Kato, T, Sugio, T, Miyawaki, K, Kamimura, T, Miyagishima, T, Eto, T, Imaizumi, Y, Kato, K, Nagafuji, K, Akashi, K, Seto, M, Teshima, T & Ohshima, K 2018, 'Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma', Oncotarget, 巻. 9, 番号 2, pp. 1717-1725. https://doi.org/10.18632/oncotarget.23138
Shimono J, Miyoshi H, Kato T, Sugio T, Miyawaki K, Kamimura T その他. Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma. Oncotarget. 2018 1 1;9(2):1717-1725. https://doi.org/10.18632/oncotarget.23138
Shimono, Joji ; Miyoshi, Hiroaki ; Kato, Takeharu ; Sugio, Takeshi ; Miyawaki, Kohta ; Kamimura, Tomohiko ; Miyagishima, Takuto ; Eto, Tetsuya ; Imaizumi, Yoshitaka ; Kato, Koji ; Nagafuji, Koji ; Akashi, Koichi ; Seto, Masao ; Teshima, Takanori ; Ohshima, Koichi. / Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma. :: Oncotarget. 2018 ; 巻 9, 番号 2. pp. 1717-1725.
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abstract = "Hepatitis C virus (HCV) is a single-stranded RNA virus that not only affects hepatocytes, by B cells as well. It is thought that HCV is involved in the onset of B-cell lymphoma. The clinicopathological characteristics of HCV-positive diffuse large B-cell lymphoma (DLBCL) and HCV-positive splenic marginal zone lymphoma (SMZL) are known, but there has been no report on HCV-positive follicular lymphoma (FL). In this study, the clinicopathological characteristics of HCV-positive FL were examined in 263 patients with FL who were classified into a HCV-positive group with HCV antibody and negative groups without one. The number of patients with HCV-positive FL and HCV-negative FL was 10 (3.8{\%}) and 253 (96.2{\%}), respectively. The patients with HCV-positive FL commonly had more than one region of lymphadenopathy, Ann Arbor stage III/IV, hemoglobin < 120 g/l, elevated lactate dehydrogenase level, and highrisk categorization of Follicular Lymphoma International Prognostic Index (FLIPI) than in patients with HCV-negative FL. Overall survival and progression-free survival were poorer in patients with HCV-positive FL than in those with HCV-negative FL (p < 0.0001 and 0.006, respectively). Also, multivariate analysis revealed that positive HCV antibody was a poor prognostic factor of OS. In conclusion, HCV-positive FL has unique clinical features and may have a great impact on the overall survival of affected patients.",
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AU - Shimono, Joji

AU - Miyoshi, Hiroaki

AU - Kato, Takeharu

AU - Sugio, Takeshi

AU - Miyawaki, Kohta

AU - Kamimura, Tomohiko

AU - Miyagishima, Takuto

AU - Eto, Tetsuya

AU - Imaizumi, Yoshitaka

AU - Kato, Koji

AU - Nagafuji, Koji

AU - Akashi, Koichi

AU - Seto, Masao

AU - Teshima, Takanori

AU - Ohshima, Koichi

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